A liposomal clodronate is an experimental treatment for certain autoimmune diseases. So far it has been used on mice, but the results are positive and promising. While the terminology used to describe what clodronate liposomes do can be complex and use difficult jargon, it is possible to describe its usage in simpler terms.
Autoimmune Hemolytic Anemia, abbreviated AIHA, is a disease which destroys the red blood cells in a person's body. Red blood cells are necessary for people to live. The way oxygen gets from your lungs to the cells of your body is by way of red blood cells. AIHA causes your white blood cells, also known as macrophages, to begin attacking your own body.
The term macrophage is made up of a couple of Greek words. Macro means 'large', while phage means 'to eat'. These 'big eaters' go around eating up the red blood cells in your body, when AIHA tells them to. This is not good because when many of your red cells are dead, your body starts to be deprived of oxygen.
Scientists are trying to find a way to stop AIHA from destroying these red cells. To do so, they invented a type of chemical that is known as a liposomal clodronate. The clodronates use a secretive process similar to the way the Trojan Horse smuggled soldiers into the city of Troy. They use this Trojan effect to sneak chemicals inside the 'big eaters' to kill them from the inside out. This makes them stop eating the red cells so your body can get the oxygen it needs.
However, this is only a temporary solution. The disease that causes the macrophages to start eating your red blood cells in the first place must be identified and stopped. The macrophages are good cells. They are part of the system that protects you against disease. But the AIHA disease causes your own white blood cells, made up in part by these macrophages, to turn against your own body and start destroying it.
When someone gets a cold, they take an antihistamine in order to treat the symptoms of their cold so that they can rest and recover from the disease itself. That is like what liposomal clodronate does. It lets doctors treat the symptoms of AIHA so that they then have time to look for and stop the disease itself.
Autoimmune Hemolytic Anemia, abbreviated AIHA, is a disease which destroys the red blood cells in a person's body. Red blood cells are necessary for people to live. The way oxygen gets from your lungs to the cells of your body is by way of red blood cells. AIHA causes your white blood cells, also known as macrophages, to begin attacking your own body.
The term macrophage is made up of a couple of Greek words. Macro means 'large', while phage means 'to eat'. These 'big eaters' go around eating up the red blood cells in your body, when AIHA tells them to. This is not good because when many of your red cells are dead, your body starts to be deprived of oxygen.
Scientists are trying to find a way to stop AIHA from destroying these red cells. To do so, they invented a type of chemical that is known as a liposomal clodronate. The clodronates use a secretive process similar to the way the Trojan Horse smuggled soldiers into the city of Troy. They use this Trojan effect to sneak chemicals inside the 'big eaters' to kill them from the inside out. This makes them stop eating the red cells so your body can get the oxygen it needs.
However, this is only a temporary solution. The disease that causes the macrophages to start eating your red blood cells in the first place must be identified and stopped. The macrophages are good cells. They are part of the system that protects you against disease. But the AIHA disease causes your own white blood cells, made up in part by these macrophages, to turn against your own body and start destroying it.
When someone gets a cold, they take an antihistamine in order to treat the symptoms of their cold so that they can rest and recover from the disease itself. That is like what liposomal clodronate does. It lets doctors treat the symptoms of AIHA so that they then have time to look for and stop the disease itself.
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