By definition, clodronate liposome is a drug delivered using liposome (a synthetic lipid that encapsulates other substances for ease of administration into the body). Liposome is manly a medium which carries the highly hydrophilic Clodronate thus facilitating its transport into the target organ. Essentially, the aim of this type of drug administration is to achieve higher macrophage depletion after an intravenous injection of the drug.
The idea behind this drug is mainly to use it as the carrier or Trojan horse to help administer drugs that would not easily reach the target organ in normal cases. Provided the liposome has been ingested and digested by the macrophages (in the spleen for instance), the Clodronate is released into the organ though intracellular activities. The resultant product is the effective bisphosphonates that can then stop the macrophage functions.
Liposome Clodronate is therefore one of those drugs under test for treatment of various terminal illnesses. Diseases such as osteoporosis, autoimmune hemolytic anemia and cancer are just a few examples. This drug can also handle metastatic carcinoma of the breast and other hard to handle conditions such as the multiple myeloma. The wide use is particularly related to its ability to inhibit the activities of macrophages even in gene therapy, neurological disorders or even transplantation therapy.
While it is still in its testing stages, the drug will not be strange since some clodronate products are already in the market to help with the treatment of excessive blood calcium. This condition is mostly seen in cancer patients. It is however encouraging that there are few mild side effects and rarely serious complications are reported. Patients using bisphosphonate products have in the past presented with nausea, vomiting and mild stomach pains.
Apart from loss of appetite, the other complications include heavy breathing, hives and skin rashes. Though some of these may not need one to see a doctor, the cases of difficulty in breathing certainly does require the attention of one. You should therefore not hesitate to report to your physician for help if the side effects take longer than normal.
Additional complications such as unknown malaise, swelling of body parts and mouth pain should also be treated with caution. Physicians in such cases may recommend treatment or drug discontinuation. It is important to note that these are not recorded drug reactions from the drug since it has not been fully put into human use. You should therefore not be discouraged in anyway.
As with all bisphosphonates and prescription medicine, you are not supposed to use them in some situations. For example, individuals with known allergies to Clodronate or bisphosphonates are advised to avoid the drug. In the same line, pregnant or breastfeeding mothers should not use the drug. In addition, kidney patients and those using bisphosphonate derivates should also avoid the drugs. Lastly, individuals having gastrointestinal inflammations are not allowed to use the the drug.
The use of clodronate liposome, like any other prescription medicine, should be a strict procedure. You are therefore not allowed to share it with other patients even if you suffer from the same disease. Additionally, you are not to borrow such drugs unless a qualified doctor prescribes them. Finally and yet importantly, you have to take the full dose without skipping if significant progress or complete healing is to be realized.
The idea behind this drug is mainly to use it as the carrier or Trojan horse to help administer drugs that would not easily reach the target organ in normal cases. Provided the liposome has been ingested and digested by the macrophages (in the spleen for instance), the Clodronate is released into the organ though intracellular activities. The resultant product is the effective bisphosphonates that can then stop the macrophage functions.
Liposome Clodronate is therefore one of those drugs under test for treatment of various terminal illnesses. Diseases such as osteoporosis, autoimmune hemolytic anemia and cancer are just a few examples. This drug can also handle metastatic carcinoma of the breast and other hard to handle conditions such as the multiple myeloma. The wide use is particularly related to its ability to inhibit the activities of macrophages even in gene therapy, neurological disorders or even transplantation therapy.
While it is still in its testing stages, the drug will not be strange since some clodronate products are already in the market to help with the treatment of excessive blood calcium. This condition is mostly seen in cancer patients. It is however encouraging that there are few mild side effects and rarely serious complications are reported. Patients using bisphosphonate products have in the past presented with nausea, vomiting and mild stomach pains.
Apart from loss of appetite, the other complications include heavy breathing, hives and skin rashes. Though some of these may not need one to see a doctor, the cases of difficulty in breathing certainly does require the attention of one. You should therefore not hesitate to report to your physician for help if the side effects take longer than normal.
Additional complications such as unknown malaise, swelling of body parts and mouth pain should also be treated with caution. Physicians in such cases may recommend treatment or drug discontinuation. It is important to note that these are not recorded drug reactions from the drug since it has not been fully put into human use. You should therefore not be discouraged in anyway.
As with all bisphosphonates and prescription medicine, you are not supposed to use them in some situations. For example, individuals with known allergies to Clodronate or bisphosphonates are advised to avoid the drug. In the same line, pregnant or breastfeeding mothers should not use the drug. In addition, kidney patients and those using bisphosphonate derivates should also avoid the drugs. Lastly, individuals having gastrointestinal inflammations are not allowed to use the the drug.
The use of clodronate liposome, like any other prescription medicine, should be a strict procedure. You are therefore not allowed to share it with other patients even if you suffer from the same disease. Additionally, you are not to borrow such drugs unless a qualified doctor prescribes them. Finally and yet importantly, you have to take the full dose without skipping if significant progress or complete healing is to be realized.
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